A Divergent de Novo Synthesis of Carbohydrates Based on an Accelerated Inverse Electron Demand Diels-Alder Reaction of 1-Oxa-1,3-butadienes

Article abstract of DOI:10.1021/jo00259a040

A divergent, de novo synthesis of selectively protected carbohydrates based on the accelerated and productive LUMO_diene-controlled <4 + 2> cycloaddition reaction of β,γ-unsaturated α-keto esters with electron-rich dienophiles (e.g., 2a,b) is detailed.