Total Synthesis of (+/-)-4'-Demethyl-4-epipodophyllotoxin by Insertion-Cyclization

DOI: 10.1021/jo00326a056

Source and publish data:

Journal of Organic Chemistry p. 2826 - 2828 (1981)

Update date:2022-08-04

Topics:

Authors:

Kende, Andrew S.

King, Margaret Logan

Curran, Dennis P.

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Article abstract of DOI:10.1021/jo00326a056

The total synthesis of (+/-)-4'-O-demethyl-4-epipodophyllotoxin (3) is accomplished in 13 steps and 2.4percent overall yield from piperonal through the use of an "insertion-cyclization" reaction to form the aryltetralin ring system.

Full text of DOI:10.1021/jo00326a056

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