Design, synthesis, and biological evaluation, of the first selective nonpeptide AT2 receptor agonist

DOI: 10.1021/jm049715t

Source and publish data:

Journal of Medicinal Chemistry p. 5995 - 6008 (2004)

Update date:2022-08-05

Topics:

Authors:

Wan, Yiqian

Wallinder, Charlotta

Plouffe, Bianca

Beaudry, Hélène

Mahalingam

Wu, Xiongyu

Johansson, Berndt

Holm, Mathias

Botoros, Milad

Karlén, Anders

Pettersson, Anders

Nyberg, Fred

F?ndriks, Lars

Gallo-Payet, Nicole

Hallberg, Anders

Alterman, Mathias

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Article abstract of DOI:10.1021/jm049715t

The first druglike selective angiotensin II AT₂ receptor agonist (21) with a K_i value of 0.4 nM for the AT₂ receptor and a Ki > 10 μM for the AT₁ receptor is reported. Compound 21, with a bioavailability of 20-3

Full text of DOI:10.1021/jm049715t

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