Nonsteroidal Antiinflammatory Agents. 3. Synthesis of the Positional Isomers of 4'-Chloro-5-methoxy-3-biphenylylacetic Acid and Their Antiinflammatory and Analgesic Activities

DOI: 10.1021/jm00140a019

Source and publish data:

Journal of Medicinal Chemistry p. 1006 - 1010 (1981)

Update date:2022-08-02

Topics:

Authors:

Tamura, Yasumitsu

Yoshimoto, Yoshihiko

Tada, Shin-ichi

Kunimoto, Katsutoshi

Matsumura, Shingo

et al. et al.

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Article abstract of DOI:10.1021/jm00140a019

The positional isomers 3a-i of 4'-chloro-5-methoxy-3-biphenylylacetic acid <1 (DKA-9), R = 4-ClPh; R' = MeO> which is a newly developed nonsteroidal antiinflammatory agent, have been prepared and evaluated for antiinflammatory and analgesic activities usi

Full text of DOI:10.1021/jm00140a019

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