New regioselective synthesis and biological activity of substituted 1H-[1,2,4]triazolo[3,4-c][1,2,4]triazoles

Article abstract of DOI:10.1002/jccs.200400054

Two regioselective synthetic approaches for the title compounds 7 via reaction of hydrazonoyl halides 1 with 3-methylthio-5-phenyl-1,2,4-triazole 3 and base-catalyzed cyclization of N-phenyl-N-(5-phenyl-s-triazol-3-yl) thiohydrazides 6 are described. The mechanisms of the reactions studied and the biological activity of the isolated products 6 and 7 are pointed out.