ON THE STEREOSELECTIVITY OF THE α-ALKYLATION OF Β-HYDROXY ESTERS. ENANTIOSELECTIVE SYNTHESIS OF 4,4- AND 6,6-DISUBSTITUTED CYCLOHEX-2-EN-1-ONES.

Article abstract of DOI:10.1016/0040-4039(81)80116-5

Stereoselective α-alkylation of the optically active β-hydroxyester 1 gives rise to 2, which was converted to the 1,5-diketone 4.Regioselective aldolcondensation of the latter furnished (S)-5 and (S)-6 respectively, each with an e.e. of 86percent.