Tetrahydrothiadiazoloisoquinolines: Synthesis and inhibition of phenylethanolamine-N-methyltransferase

DOI: 10.1021/jm00127a027

Source and publish data:

Journal of Medicinal Chemistry p. 1566 - 1571 (1989)

Update date:2022-08-04

Topics:

Authors:

Girard Girard

Bondinell

Hillegass

Holden Holden

Pendleton

Uzinskas

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Article abstract of DOI:10.1021/jm00127a027

A series of 7,8-fused heterocyclic tetrahydroisoquinolines were synthesized and tested as inhibitors of rabbit adrenal phenylethanolamine-N-methyltransferase (PNMT). 6,7,8,9-Tetrahydro[1,2,3]thiadiazolo[5,4-h]isoquinoline 5 (SK and F 86607) was found to b

Full text of DOI:10.1021/jm00127a027

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