Synthesis and properties of oligodeoxyribonucleotides containing 2′-O-(2,3-dihydroxypropyl)- and 2′-O-(2-oxoethyl)arabinouridine residues

Article abstract of DOI:10.1007/s11172-005-0243-2

2′-O-(2,3-Dihydroxypropyl)arabinouridine-containing oligodeoxyribonucleotides were synthesized starting from a new modified nucleoside, viz., 2′-O-(2,3-dihydroxypropyl)arabinouridine, and the corresponding 3′-phosphoramidite. Oxidation of these oligodeoxy