Selective and potent β2-adrenoceptor agents within the tetrahydroisoquinoline class: Effect of methyl substitution at the benzylic carbon of the 1-(3,4,5-trimethoxybenzyl) group of trimetoquinol

Article abstract of DOI:10.1021/jm00140a011

A systematic series of methyl (2 and 3) and dimethyl (4) analogues of trimetoquinol (1) were synthesized and evaluated for their β₁ (atria) and β₂ (trachea) adrenoceptor activities. Structural assignments for the erythro (2) and the