Selective and potent β2-adrenoceptor agents within the tetrahydroisoquinoline class: Effect of methyl substitution at the benzylic carbon of the 1-(3,4,5-trimethoxybenzyl) group of trimetoquinol

DOI: 10.1021/jm00140a011

Source and publish data:

Journal of Medicinal Chemistry p. 970 - 974 (1981)

Update date:2022-08-04

Topics: Tetrahydroisoquinoline

Authors:

Sober Sober

Chang Chang

Fowble Fowble

Mukhopadhyay

Feller Feller

Miller Miller

Fairchild

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Article abstract of DOI:10.1021/jm00140a011

A systematic series of methyl (2 and 3) and dimethyl (4) analogues of trimetoquinol (1) were synthesized and evaluated for their β₁ (atria) and β₂ (trachea) adrenoceptor activities. Structural assignments for the erythro (2) and the

Full text of DOI:10.1021/jm00140a011

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