Journal of Organic Chemistry p. 3853 - 3856 (1981)
Update date:2022-09-26
Topics:
Press, Jeffery B.
Eudy, Nancy H.
Olagbemiro, Timothy O.
The title compound 2 was prepared in four steps from diethyl 3,4-furandicarboxylate.Reactions of 2 with nitrogen and oxygen nucleophiles occur exclusively at the nitrogen carbonyl to give ureido acids 6 or carbamato acids 8 under a variety of reaction conditions.The results are in contrast to the reactions of isatoic anhydride 1.In order to achieve substitution at the carbonyl adjacent to the furan ring, carbamato acid 8a was derivatized with subsequent deprotection of the amine.In this manner, furo<3,4-d><1,3>oxazines 14a-d were prepared.Several possible reasons for the reactivity of 2 are presented.
View MoreContact:+65 9658 0999
Address:26 Sin Ming Lane, Midview City, #05-118, Singapore 573971
wuxi leji biology technology co., LTD
website:http://www.lejibio.com/
Contact:18362718864
Address:The Nanyue Road No. 2, Yixing City, Jiangsu Province
Shandong Xinke Petrochemical Co., Ltd.
Contact:+86-546-7277016
Address:Gudao Industrial Park, Hekou District, Dongying, Shandong Province, China
Zhejiang Kangfeng Chemical Co.,LTD.
Contact:+86-579-86709687
Address:Xueshizhai Industrial Zone, Weishan Town,Dongyang City, Zhejiang Province ,China
Yangling Ciyuan biotech Co., Ltd.
Contact:86-15802970736
Address:2-1804, International Park Mansion, No.2, South Fengdeng Road, Lianhu District
Doi:10.1016/S0040-4039(01)90286-2
(1981)Doi:10.1021/jm00141a002
(1981)Doi:10.1002/hlca.19810640224
(1981)Doi:10.1007/BF00519811
(1985)Doi:10.1039/b411158c
(2004)Doi:10.1016/S0040-4039(01)90328-4
(1981)