A Dopamine Receptor Model and Its Application in the Design of a New Class of Rigid Pyrroloisoquinoline Antipsychotics

DOI: 10.1021/jm00141a002

Source and publish data:

Journal of Medicinal Chemistry p. 1026 - 1034 (1981)

Update date:2022-09-26

Topics: Selectivity Molecular docking Pharmacophore binding affinity Lead Optimization Structure-Activity Relationship (SAR) Conformational Restriction Heterocyclic compound Neurotransmitter Radioligand Binding Assay

Authors:

Olson, Gary L.

Cheung, Ho-Chuen

Morgan, Keith D.

Blount, John F.

Todaro, Louis

et al. et al.

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Article abstract of DOI:10.1021/jm00141a002

A hypothetical model of the interaction of antipsychotic drugs with the dopamine receptor is described.This three-dimensional molecular model has been developed on the basis of plausible intermolecular interactions between pharmacophoric groups of diverse

Full text of DOI:10.1021/jm00141a002

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