Journal of Medicinal Chemistry p. 1059 - 1063 (1981)
Update date:2022-08-02
Topics:
Tenthorey, Paul A.
Adams, H. Jack
Kronberg, George H.
Takman, Bertil H.
A series of 2,3-diaminopropionanilides was synthesized by acylation of mono- and disubstituted aniline derivatives with 2,3-dibromopropionyl chloride and subsequent amination with the appropiate secondary amines.The target compounds were evaluated in mice for antiarrhythmic efficacy against chloroform-induced tachycardia and for central nervous system toxicity.Several of the active agents were found to have much higher antiarrhythmic potencies than lidocaine, but they were also toxic.Evaluation of the target compounds for local anesthetic activity in the formof sciatic nerve block in rats showed that most compounds had durations of block similar to that of lidocaine; none exhibited the long duration of block seen with etidocaine.
View Morefujian quanzhoushi boshi environmental protecyion project co.ltd
Contact:+8615905095093
Address:208 xuefu shangcheng store,chengdong street,fengze district,quanzhou city,fujian province,China
Contact:0086 371 65711996
Address:Jalan 4/3, Kawasan Perindustrian Serendah, 48000 Rawang,
Suzhou Kangrun Pharmaceutical, Inc
Contact:86-512-63912376，63913329
Address:Building 2, No. 2358 ,Chang'an Rd, Wujiang Economic Development Zone Pioneering park, china
Neworld Chemical Co., Ltd Shanghai(expird)
Contact:+86-21-62202658
Address:11F, Blvd 2, No. 1969 PuXing Rd, Shanghai
Lanling Hongchuang Flame Retardant Co., Ltd.
Contact:+86-531-68858132
Address:East Huafeichang Road, Cangshan County, Linyi, Shandong, China (Mainland)
Doi:10.1002/ejoc.200600123
(2006)Doi:10.1021/jm100697g
(2010)Doi:10.1002/ejoc.201600051
(2016)Doi:10.1016/S0272-6386(05)80003-4
(1944)Doi:10.1021/jo00333a021
(1981)Doi:10.1021/ja00766a070
(1972)
