Study of Charge-transfer Interaction in Biomolecules

Article abstract of DOI:10.1039/f19817701405

The interaction of the antibiotic drugs tetracycline and oxytetracycline with purines, pyrimidines and amino acids were studied spectrophotometrically in water, ethylene glycol and propylene glycol.In each case a new absorption band was located and denoted as a charge-transfer band.The formation constants for the charge-transfer complexes were determined using Benesi-Hildebrand's method followed by an iterative procedure.Different linear plots for hν against the highest filled ?-molecular orbital of the donors (purines, pyrimidines and amino acids) were obtained indicating different stabilization energies for each system.