Synthesis and antitumor activities of novel benzoylphenylurea derivatives

DOI: 10.1248/cpb.39.2308

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2308 - 2315 (1991)

Update date:2022-08-03

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Authors:

Okada Okada

Koyanagi

Yamada Yamada

Haga Haga

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Article abstract of DOI:10.1248/cpb.39.2308

Seventy novel benzoylphenylurea compounds were synthesized and their antitumor activities were examined in vivo against P388 leukemia. N-(2-Nitrobenzoyl)-N'-[4-(2-pyrimidinyloxy)phenyl]ureas showed the highest antitumor activities when dosed intraperitoneally or orally. Their structure-activity relationships were examined with particular focus on the position and the variety of substituent on each aryl ring.

Full text of DOI:10.1248/cpb.39.2308

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