Chemical and Pharmaceutical Bulletin p. 2308 - 2315 (1991)
Update date:2022-08-03
Topics:
Okada
Koyanagi
Yamada
Haga
Seventy novel benzoylphenylurea compounds were synthesized and their antitumor activities were examined in vivo against P388 leukemia. N-(2-Nitrobenzoyl)-N'-[4-(2-pyrimidinyloxy)phenyl]ureas showed the highest antitumor activities when dosed intraperitoneally or orally. Their structure-activity relationships were examined with particular focus on the position and the variety of substituent on each aryl ring.
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Doi:10.1248/cpb.29.1439
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