Studies on 2-oxoquinoline derivatives as blood platelet aggregation inhibitors. II. 6-[3-(1-Cyclohexyl-5-tetrazolyl)propoxy]-1,2-dihydro-2-oxoquinoline and related compounds

DOI: 10.1248/cpb.31.1151

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1151 - 1157 (1983)

Update date:2022-08-04

Topics:

Authors:

Nishi Nishi

Tabusa Tabusa

Tanaka Tanaka

Shimizu Shimizu

Kanbe Kanbe

Kimura Kimura

Nakagawa

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Article abstract of DOI:10.1248/cpb.31.1151

A series of ω-(1-substituted-5-tetrazolylalkoxy)-2-oxoquinolines was synthesized and tested for inhibitory activity towards collagen- and adenosine diphosphate (ADP)-induced aggregation of rabbit blood platelets in vitro. These compounds were prepared by the reaction of 1-substituted-5-(ω-chloroalkyl)-tetrazoles and hydroxy-2-oxoquinolines in the presence of a base. Among them, 6-[3-(1-cyclohexyl-5-tetrazolyl)propoxy]-1,2-dihydro-2-oxoquinoline (IVb) was found to have the most potent inhibitory activity. The structure-activity relationships are discussed.

Full text of DOI:10.1248/cpb.31.1151

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