Structural features resulting in convulsive activity of carbapenem compounds: Effect of C-2 side chain

Article abstract of DOI:10.7164/antibiotics.48.408

The neurotoxicity of meropenem was much lower than that of both imipenem and panipenem after intraventricular administration to mice. To clarify the major structural features responsible for the induction of convulsions by carbapenem antibiotics, the stru