Chemistry of Natural Compounds p. 142 - 145 (1981)
Update date:2022-08-04
Topics:
Kamernitskii, A. V.
Krivoruchko, V. A.
Reshetova, I. G.
Chernoburova, E. I.
The synthesis of the Δ17(20)-16α analog of natural chiogralactone is described.Attempts to introduce a 6-oxo group directly into the δ-lactone proved unsuccessful, since the first stage - saponification - took place with the formation of three products: the 3-hydroxy-δ-lactone, the 3-hydroxy-Δ20(22)-lactone, and the 15,17(20)-dienoic acid.The synthesis of the desired compound was effected from the ethyl ester of the 5,16-dienoic acid by the scheme 3-acetate->3-tosylate->6-hydroxy-3α,5α-cyclosteroid->6-oxo-3α,5α-cyclosteroid->6-oxo-5αH-δ-lactone.It has been shown that the cyclopropane ring in the 3α,5α-cyclosteroid δ-lactone is extremely stable under the conditions of acid treatments.
View MoreJinan Jinguilin Chemical Co.,Ltd
Contact:+86-531-81188412
Address:3rd floor of Torch Building, Huanyuan Rd, City of Jinan
Shandong Shouguang Songchuan Industrial Additives Co.,Ltd
Contact:+86-536-8566856
Address:Shouguang,Shandong,China
website:http://www.dulynet.com/
Contact:025-84699383 -8003
Address:Room 503, Building 2, Chuangxinhui, No. 61 Wenjing Road, High-tech Development Zone, Pukou District, Nanjing City, Jiangsu Province Nanjing, Jiangsu
Luojiang Chenming Biological Products Co
Contact:+86 15000297032
Address:GROUP NO.4, HE SHENG VILLAGE, PANLONG TOWN,
Arshine Pharmaceutical Co., Limited
website:http://www.cnarshine.com
Contact:0731-88503671
Address:Room 1109.Block C3, Lugu Enterprise Plaza,No.27 Wenxuan Road,Changsha National Hi-Tech Industrial Development Zone,Hunan ,P.R.China
Doi:10.1016/j.tetlet.2020.152269
(2020)Doi:10.1016/j.jorganchem.2004.08.013
(2004)Doi:10.1016/j.tetlet.2017.04.061
(2017)Doi:10.1021/jo00341a034
(1982)Doi:10.1016/00404-0399(50)1197P-
(1995)Doi:10.1016/j.bmcl.2006.11.014
(2007)
