Chemistry of Natural Compounds p. 142 - 145 (1981)
Update date:2022-08-04
Topics:
Kamernitskii, A. V.
Krivoruchko, V. A.
Reshetova, I. G.
Chernoburova, E. I.
The synthesis of the Δ17(20)-16α analog of natural chiogralactone is described.Attempts to introduce a 6-oxo group directly into the δ-lactone proved unsuccessful, since the first stage - saponification - took place with the formation of three products: the 3-hydroxy-δ-lactone, the 3-hydroxy-Δ20(22)-lactone, and the 15,17(20)-dienoic acid.The synthesis of the desired compound was effected from the ethyl ester of the 5,16-dienoic acid by the scheme 3-acetate->3-tosylate->6-hydroxy-3α,5α-cyclosteroid->6-oxo-3α,5α-cyclosteroid->6-oxo-5αH-δ-lactone.It has been shown that the cyclopropane ring in the 3α,5α-cyclosteroid δ-lactone is extremely stable under the conditions of acid treatments.
View MoreContact:0086-27-83607103/83642615
Address:No.498, Jianshe Ave, Wuhan, China
Engineering Research Center of Pesticide, Heilongjiang Province
Contact:+86-451-86609001
Address:No.74 of Xuefu Road, Nangang District,
Oren Hydrocarbons (Qingdao) Co., Ltd.
Contact:+86-532-68607667-801
Address:Room 3 # 302, No.9 Qingyun Road, Qingdao, China
Xiamen Hisunny Chemical Co.,Ltd
website:http://www.hisunnychem.com
Contact:+86-592-3327115
Address:Unit 603,No.879,Xiahe Road,Meixin Building,Xiamen,China
SHIJIAZHUANG AGERUO-BIOTECH CO.LTD
Contact:+86-130-2866-6699
Address:Huaian east Road 158
Doi:10.1016/j.tetlet.2020.152269
(2020)Doi:10.1016/j.jorganchem.2004.08.013
(2004)Doi:10.1016/j.tetlet.2017.04.061
(2017)Doi:10.1021/jo00341a034
(1982)Doi:10.1016/00404-0399(50)1197P-
(1995)Doi:10.1016/j.bmcl.2006.11.014
(2007)
