ASYMMETRIC REDUCTION OF KETONES USING LiAlH4 MODIFIED WITH CHIRAL 1,2-AMINODIOLS

Article abstract of DOI:10.1016/S0040-4039(01)92952-1

Four chiral aminodiols from ring opening of (S)-propylene oxide and ethylene oxide with n-butylamine and (R) or (S)-α-methylbenzylamine were used to modify LiAlH4.Asymmetric reduction of acetophenone and propiophenone gave the highest percent enantiomeric