Synthesis p. 549 - 552 (1997)
Update date:2022-08-03
Topics:
Igarashi, Yoshio
Otsutomo, Shinya
Harada, Masayuki
Nakano, Shigeru
Watanabe, Shoji
Lipase-mediated resolution of indene bromohydrin was examined, and we have found that immobilized CAL (Candida antarctica lipase SP525 immobilized on acurrell) was an efficient biocatalyst to resolve a readily available racemic indene bromohydrin (+)-1. Enantiomerically enriched (1R,2R)-2- bromoindan-1-ol (-)-1 and its (1S,2S)-acetate (+)-2 were obtained by this method.
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(1992)
