Chemical adaptor immunotherapy: Design, synthesis, and evaluation of novel integrin-targeting devices

Article abstract of DOI:10.1021/jm049666k

A series of β-diketone derivatives of RGD peptidomimetics that selectively bind to αvβ3 and αvβ5 integrins were synthesized and covalently docked to the reactive lysine residues of monoclonal aldolase antibody 38C2. The resulting targeting devices strongl