Journal of Fluorine Chemistry p. 483 - 496 (1981)
Update date:2022-08-05
Topics:
Filler, Robert
Rickert, Robert C.
DL-2,5,6-trifluoro-3,4-dihydroxyphenylalanine (trifluorodopa) hydroiodide has been synthesized from hexafluorobenzene in a six-step procedure.The key step is the methoxylation of p-methyl tetrafluoroanisole.This reaction affords the desired 2,5,6-trifluoro-3,4-dimethoxytoluene, which is separated by preparative glc from 3,5,6-trifluoro-2,4-dimethoxytoluene.Attempts to obtain trifluorodopa by ether cleavage of the appropriately substituted dihydrobenzodioxin have not been successful.
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(1982)Doi:10.1246/cl.1981.1297
(1981)Doi:10.1016/j.bmcl.2005.11.048
(2006)Doi:10.1016/j.bmcl.2004.08.062
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(1982)Doi:10.1248/cpb.29.3281
(1981)
