Journal of Fluorine Chemistry p. 483 - 496 (1981)
Update date:2022-08-05
Topics:
Filler, Robert
Rickert, Robert C.
DL-2,5,6-trifluoro-3,4-dihydroxyphenylalanine (trifluorodopa) hydroiodide has been synthesized from hexafluorobenzene in a six-step procedure.The key step is the methoxylation of p-methyl tetrafluoroanisole.This reaction affords the desired 2,5,6-trifluoro-3,4-dimethoxytoluene, which is separated by preparative glc from 3,5,6-trifluoro-2,4-dimethoxytoluene.Attempts to obtain trifluorodopa by ether cleavage of the appropriately substituted dihydrobenzodioxin have not been successful.
View MoreContact:+86-21-54391580
Address:Room 502,No.65,Lane 2388 Hongxin Road,Shanghai,China
Shanghai Sungo Technology Chemical Co., Ltd
Contact:0086-21-51385579
Address:Room2010, F/20, Tonghua Plaza, NO 345 Jinxiang Road, Jinqiao Export Processing Zone, Shanghai, 201206 P.R.CHINA
Contact:+86-21-6856-1349 523-87676172
Address:No16 . BinJiang Road . Taixing Economy Developing Area .JiangSu Province . China
Shanghai Coupling Pharmaceutical R&D Co., Ltd.(expird)
Contact:+86 021 50106671
Address:403 Room No.4 Buiding, No. 526 Ruiqing Road, Shanghai Zhangjiang Hi-Tech Park
Ji'nan Orgachem Pharmaceutical Co.,Ltd
Contact:+86-531-82687810
Address:Jinan
Doi:10.1021/jo00348a029
(1982)Doi:10.1246/cl.1981.1297
(1981)Doi:10.1016/j.bmcl.2005.11.048
(2006)Doi:10.1016/j.bmcl.2004.08.062
(2004)Doi:10.1021/ja00371a040
(1982)Doi:10.1248/cpb.29.3281
(1981)
