Journal of Fluorine Chemistry p. 483 - 496 (1981)
Update date:2022-08-05
Topics:
Filler, Robert
Rickert, Robert C.
DL-2,5,6-trifluoro-3,4-dihydroxyphenylalanine (trifluorodopa) hydroiodide has been synthesized from hexafluorobenzene in a six-step procedure.The key step is the methoxylation of p-methyl tetrafluoroanisole.This reaction affords the desired 2,5,6-trifluoro-3,4-dimethoxytoluene, which is separated by preparative glc from 3,5,6-trifluoro-2,4-dimethoxytoluene.Attempts to obtain trifluorodopa by ether cleavage of the appropriately substituted dihydrobenzodioxin have not been successful.
View MoreImprove Medical Technology(Nanxiong) Co., Ltd
Contact:86-751-3836997
Address:No.33, Pingan First Road, Fine Chemical Industry Base, Nanxiong City, Shaoguan, Guangdong, China
Shanghai Coupling Pharmaceutical R&D Co., Ltd.(expird)
Contact:+86 021 50106671
Address:403 Room No.4 Buiding, No. 526 Ruiqing Road, Shanghai Zhangjiang Hi-Tech Park
Shanghai Hohance Chemical Co., ltd
Contact:13914753421
Address:Fl.5;Bld. 70, Lane 1500; Xinfei Road
Shanghai Longjin Metallic Material Co., Ltd.
website:http://www.shlongjin.cn/
Contact:021-56517503,56502257
Address:No.16, Lane 555, Chengyin Road, Shanghai
website:http://www.maisonchem.com.cn
Contact:0086-311-83833777
Address:Leitou industrial district, xinji, shijiazhuang city, hebei province,
Doi:10.1021/jo00348a029
(1982)Doi:10.1246/cl.1981.1297
(1981)Doi:10.1016/j.bmcl.2005.11.048
(2006)Doi:10.1016/j.bmcl.2004.08.062
(2004)Doi:10.1021/ja00371a040
(1982)Doi:10.1248/cpb.29.3281
(1981)