Singlet oxygen oxidation of pyrroles: Synthesis and chemical transformations of novel 4,4-bis(trifluoromethyl)imidazoline analogs

DOI: 10.1016/0040-4020(96)00578-9

Source and publish data:

Tetrahedron p. 11153 - 11162 (1996)

Update date:2022-08-05

Topics:

Authors:

Li, Hui-Yin

Drummond, Spencer

DeLucca, Indawati

Boswell, George A.

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Article abstract of DOI:10.1016/0040-4020(96)00578-9

A novel singlet oxygen ring cleavage of pyrrole 5a and subsequent acid-catalyzed facile dehydrocyclization afforded a new series of 4,4-bis(trifluoromethyl)imidazolines with a p-fluorophenacyl side chain at the 5-position, which have shown potent acyl CoA: cholesterol acyltransferase (ACAT) and cholesterol biosynthesis inhibitory activities.

Full text of DOI:10.1016/0040-4020(96)00578-9

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Product name:α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1H-pyrrole-2-methanamine

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