Irreversible Enzyme Inhibitors. 202. Candidate Active-Site-Directed Irreversible Inhibitors of 5-Fluoro-2'-deoxyuridine Phosphorylase from Walker 256 Rat Tumor Derived from 1-Benzyl-5-(3-ethoxybenzyl)uracil

DOI: 10.1021/jm00347a022

Source and publish data:

Journal of Medicinal Chemistry p. 600 - 603 (1982)

Update date:2022-08-05

Topics:

Authors:

Kelley, James L.

Baker, B. R.

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Article abstract of DOI:10.1021/jm00347a022

Six candidate irreversible inhibitors of uridine-deoxyuridine phosphorylase (EC 2.4.2.3) from Walker 256 rat tumor were synthesized.These compounds connect a terminal sulfonyl fluoride group to the 1-benzyl moiety of 1-benzyl-5-(3-ethoxybenzyl)uracil (9).

Full text of DOI:10.1021/jm00347a022

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