Potential inhibitors of nucleotide biosynthesis. 2. Halomethyl ketone derivatives of pyrimidine nucleosides

Article abstract of DOI:10.1021/jm00371a022

Several halomethyl ketone derivatives of pyrimidine nucleosides have been prepared for evaluation as cytotoxic agents. The first series are 1-(8-halo-2,5,6,8-tetradeoxy-β-D-erythro-oct-7-ulofuranosyl)thymines, whereas the second type are halo derivatives