Journal of Organic Chemistry p. 1221 - 1228 (1982)
Update date:2022-08-03
Topics:
Jakubowski, Ann A.
Guziec, Frank S.
Sugiura, Marsaru
Tam, Coretta Chan
Tishler, Max
Omura, Satoshi
The total synthesis of the microbial metabolite (+/-)-cerulenin (1) is described.Detailed evidence for the cyclization of cerulenin to a mixture of hydroxy lactams 2 is presented.The successful synthetic approach to cerulenin uses butenolide 3 as a key intermediate.Sodium hypochlorite in pyridine was found to epoxidize the butenolide system nicely; all other methods investigated failed.The syntheses of (+/-)-tetrahydrocerulenin 25 and a number of related compounds are also described.
View MoreHubei Sibo Technology Co.,Ltd.
Contact:0715-6597222
Address:Pan Jia Wan fan Lake Chemical Industrial Park ,Xianning City, Hubei, China
Beijing Top Science biological technology co., LTD
Contact:+86-13439059536
Address:15-1705 jre three mile, Beijing 100000,CHINA
Baicao Pharmaceutical Co., Ltd.
website:http://www.jxbaicao.com
Contact:+86-796-8113329
Address:It (country) economic and technological development zone of the jinggang mountains
Contact:+86-310-7092106
Address:Quzhou Modern & New Industrial Park, Handan, Hebei 057250, China
Contact:27-792-602929
Address:SIDNEY MUFAMADI STREET 009949 X44 0700 POLOKWANE,LIMPOPO
Doi:10.1021/ol0702728
(2007)Doi:10.1016/j.bmcl.2016.02.077
(2016)Doi:10.1055/s-1980-28957
(1980)Doi:10.1016/S0040-4020(01)87351-8
(1986)Doi:10.1039/b417538g
(2005)Doi:10.1021/acs.joc.0c02088
(2020)
