Journal of Organic Chemistry p. 1221 - 1228 (1982)
Update date:2022-08-03
Topics:
Jakubowski, Ann A.
Guziec, Frank S.
Sugiura, Marsaru
Tam, Coretta Chan
Tishler, Max
Omura, Satoshi
The total synthesis of the microbial metabolite (+/-)-cerulenin (1) is described.Detailed evidence for the cyclization of cerulenin to a mixture of hydroxy lactams 2 is presented.The successful synthetic approach to cerulenin uses butenolide 3 as a key intermediate.Sodium hypochlorite in pyridine was found to epoxidize the butenolide system nicely; all other methods investigated failed.The syntheses of (+/-)-tetrahydrocerulenin 25 and a number of related compounds are also described.
View MoreContact:+86-15995924277
Address:WuZhongOu suzhou new south road 89
website:https://sdjingyuan.lookchem.com/
Contact:86-531-82687998
Address:Factory Building 11, Jinan Comprehensive free trade zone, Shandong, China
Contact:+86-574-89075960
Address:#100 Xiang Yun Road, New High tech area, Ningbo, China
NANCHANG QINZHI SCI&TEC.CO.,LTD(expird)
Contact:+86-13687004106
Address:Hero South Road,Hero Zone,Nanchang,Jiangxi,China
Tianjin Ji Ping Jia Chemical Co., Ltd.
Contact:18622448868
Address:tianjin
Doi:10.1021/ol0702728
(2007)Doi:10.1016/j.bmcl.2016.02.077
(2016)Doi:10.1055/s-1980-28957
(1980)Doi:10.1016/S0040-4020(01)87351-8
(1986)Doi:10.1039/b417538g
(2005)Doi:10.1021/acs.joc.0c02088
(2020)
