Journal of the Chemical Society. Chemical communications p. 668 - 669 (1980)
Update date:2022-08-04
Topics:
Fujino, Masahiko
Nishimura, Osamu
Wakimasu, Mitsuhiro
Kitada, Chieko
The 4-methoxy-2,6-dimethylbenzenesulphonyl (Mds) group for the protection of the guanidino function, which is readily removed with trifluoroacetic acid-thioanisole but is resistant to hydrogenolysis or treatment with dilute hydrogen chloride, can be used in the solution synthesis of arginine-containing peptides; this protecting group was effectively used in the synthesis of substance P and two LH-RH analogues.
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(1981)
