Bioorganic and Medicinal Chemistry Letters p. 5851 - 5853 (2004)
Update date:2022-08-04
Topics:
Kashiwada, Yoshiki
Sekiya, Michiko
Ikeshiro, Yasumasa
Fujioka, Toshihiro
Kilgore, Nicole R.
Wild, Carl T.
Allaway, Graham P.
Lee, Kuo-Hsiung
3-O-Glutaryl-dihydrobetulin (17) demonstrated extremely potent anti-HIV activity with an EC50 value of 2 × 10-5 μM and a TI value of 1.12 × 106. 3-O-(3′,3′- Dimethylsuccinyl)- and 3-O-(3′,3′-dimethylglutaryl)-dihydrobetulins (15, 16) were also potent anti-HIV compounds with EC50 values of 0.0017 and 0.0013 μM, respectively, and TI values of 16,160 and 19,530, respectively. 3-O-Acyl-betulin and -dihydrobetulin derivatives were prepared and evaluated for anti-HIV activity. 3-O-Glutaryl-dihydrobetulin (17) demonstrated extremely potent anti-HIV activity with an EC50 value of 2 × 10-5 μM and a TI value of 1.12 × 106. 3-O-(3′,3′-Dimethylsuccinyl)- and 3-O-(3′,3′- dimethylglutaryl)-dihydrobetulins (15, 16) were also potent anti-HIV compounds with EC50 values of 0.0017 and 0.0013 μM, respectively, and TI values of 16,160 and 19,530, respectively.
View MoreAnqing World Chemical Co., Ltd.
Contact:+86-556-5800026
Address:Daguan Economic Development Zone of circular economy industrial park Anqing City Anhui province
Beijing Zhongshuo Pharmaceutical T & D Co.,Ltd
Contact:0086-10-64430626
Address:ea No 16, HEPINGLI,DONGCHENG DISTRICT,BEIJING,P.R.CHINA.
Shanghai Bojing Chemical Co., Ltd.
Contact:021-37122233
Address:6F Buildiing 11,No.388,Baifu Road,District Fengxian.Shanghai, China.
Junkai (Tianjin) Chemical Co., Ltd.
website:http://www.junkaichem.com
Contact:86-22-85689515
Address:Room 8-501, Building K2, The Hi-Tech Green Industrial Base, No.6, 6th Road, Hi-Tech Development Road, Tianjin Hi-Tech IndustrialPark, Tianjin, China.
NanJing Rate Biochemicals CO., LTD
Contact:+86-25-84931986
Address:NO. 1 Hongjing Road,Jiangning Science Park,Nanjing,China
Doi:10.1021/acs.joc.7b01061
(2017)Doi:10.1002/ardp.19813140809
(1981)Doi:10.1016/S0008-6215(00)85601-3
(1981)Doi:10.1021/ja01874a023
(1939)Doi:10.1021/ma0493527
(2004)Doi:10.1016/j.bmc.2004.07.035
(2004)