CHIMIE ORGANOMETALLIQUE. XXII. SYNTHESE D'ARENES SUBSTITUES PAR ADDITION D'UN NUCLEOPHILE A UN ARENE CHROME TRICARBONYLE PUIS PAR DECOMPLEXATION OXYDANTE DU METAL

Article abstract of DOI:10.1016/S0022-328X(00)89049-X

The product distribution obtained in addition reactions of ^-CH(CH3)CN to an arenechromium tricarbonyl is studied.The major product obtained after oxidative removal of the metal corresponds to nucleophilic addition on an arene carbon atom which is in an eclipsed position with respect to the carbonyl group of the Cr(CO)3 unit of the most stable conformer.The synthesis of the corresponding acid represents an example of arenechromium tricarbonyl chemistry applied to synthesis of an organic compound having pharmaceutical properties and which by classical methods could only be synthesized via a multi step process.