NEW TYPE OF PREFABRICATED FULLY PROTECTED RIBONUCLEOTIDE MONOMER UNITS AS USEFUL SYNTHETIC INTERMEDIATES IN RAPID OLIGORIBONUCLEOTIDE SYNTHESIS

DOI: 10.1246/cl.1982.15

Source and publish data:

Chemistry Letters p. 15 - 18 (1982)

Update date:2022-07-30

Topics: Oxidation Solid-phase synthesis Yield Nucleoside Mass spectrometry (MS) Deprotection Activation Capping Synthetic intermediates Oligoribonucleotide fully protected HPLC purification Annealing Phosphoramidite chemistry Coupling efficiency

Authors:

Honda, Sinkichi

Terada, Kazunori

Sato, Yoshinobu

Sekine, Mitsuo

Hata, Tsujiaki

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Article abstract of DOI:10.1246/cl.1982.15

Oligoribonucleotide synthesis has been done by employing newly constructed fully protected ribonucleotide units, S,S-diphenyl 5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N-monomethoxytrityl-nucleoside 3'-phosphorodithioates 7.The units were found to be us

Full text of DOI:10.1246/cl.1982.15

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