Development of a control strategy for a defluorinated analogue in the manufacturing process of casopitant mesylate

DOI: 10.1021/op1000836

Source and publish data:

Organic Process Research and Development p. 832 - 839 (2010)

Update date:2022-09-26

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Authors:

Bravo, Fernando

Cimarosti, Zadeo

Tinazzi, Francesco

Castoldi, Damiano

Stonestreet, Paul

Galgano, Annalisa

Westerduin, Pieter

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Article abstract of DOI:10.1021/op1000836

Casopitant mesylate was identified as part of the search for drugs with activity on the Central Nervous System (CNS) by GlaxoSmithKline. During late-phase development studies to develop the manufacturing process, a new impurity was found. This synthetic i

Full text of DOI:10.1021/op1000836

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