STUDIES ON AMINO ACIDS AND PEPTIDES-I SYNTHESIS OF N-BENZYLOXYCARBONYLENDOTHIODIPEPTIDE ESTERS

Article abstract of DOI:10.1016/S0040-4020(01)98892-1

N-Benzyloxycarbonylendothiodipeptide esters, 3, are synthesized without racemization from the corresponding N-benzyloxycarbonyldipeptide esters, 2, using 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide, 1, as thionation reagent.The benzyloxycarbonyl amino-protecting group (Z) is removed from 3 by using HBr-AcOH.