Tetrahedron p. 4097 - 4109 (1981)
Update date:2022-08-03
Topics:
Nicolaou, K.C.
A number of organoselenium reagents are introduced as efficient initiators of ring closures leading from unsaturated substrates to lactones, cyclic ethers, cyclic thioethers, N-heterocycles and carbocycles.These cyclizations often proceed with high ring selectivity and stereoselectivity and are accompained by the incorporation of the phenylseleno group (PheSe) into the final product.Methods are described for the effective removal of this group (PheSe) by oxidation or reduction achieving unsaturation or saturation.Finally the successful application of this Se-based methodology to the synthesis of stable and biologically active prostacyclins is outlined.Representative experimental procedures are included.
View MoreContact:0572-2722882
Address:1201,F3,xinghuibandao,
Contact:86-371-63655023
Address:No.85,jinshui road,zhengzhou,China
Shandong General Materials Co.,Ltd（Shandong Aoertong Chemical Co., Ltd）
Contact:86-531-88072280
Address:No. 1825 Hualong Road, Licheng District, Jinan, Shandong, China
Changzhou Ansciep Chemical Co.,Ltd.
Contact:+86 519 8630 5871
Address:A-710 Boan International, 8 East Guangdian Road,Wujin,Changzhou
website:http://www.shtopchem.com/
Contact:0086-0576-87776998
Address:room no 1608,xuhui business building yude road,xujiahui street, xuhui district
Doi:10.1016/j.tet.2015.11.034
(2016)Doi:10.1021/jo00141a031
(1982)Doi:10.1016/j.tet.2004.09.074
(2004)Doi:10.1002/jlac.198219820308
(1982)Doi:10.1021/jo00138a017
(1982)Doi:10.1021/acs.orglett.7b02168
(2017)
