Tetrahedron p. 11493 - 11501 (2004)
Update date:2022-08-02
Topics:
Danieli, Chiara
Ghelfi, Franco
Mucci, Adele
Pagnoni, Ugo M.
Parsons, Andrew F.
Pattarozzi, Mariella
Schenetti, Luisa
The reaction of 4-methyl-pyrrolidin-2-ones, chlorinated at the C(3) and C(6) positions, with n-propylamine constitutes a new method for the preparation of 5-propylimino-pyrrolidin-2-ones or 3-pyrrolin-2-ones in generally good yields. The transformation involves a series of eliminations, substitutions and double bond shifts. This constitutes a remarkable example of a functional rearrangement. Graphical Abstract.
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(2004)
