2-(4-Amino-4-carboxybutyl)aziridine-2-carboxylic acid. A potent irreversible inhibitor of diaminopimelic acid epimerase. Spontaneous formation from α-(halomethyl)diaminopimelic acids

DOI: 10.1021/jm00170a018

Source and publish data:

Journal of Medicinal Chemistry p. 2157 - 2162 (1990)

Update date:2022-08-03

Topics:

Authors:

Gerhart Gerhart

Higgins Higgins

Tardif Tardif

Ducep Ducep

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Article abstract of DOI:10.1021/jm00170a018

2-(4-Amino-4-carboxybutyl)aziridine-2-carboxylic acid (3) (aziridino-DAP) was identified as the product of spontaneous hydrolysis of α-(halomethyl)diaminopimelic acids (α-halomethyl-DAPs) 2a-c. Under physiological conditions, 3 is an extremely potent irre

Full text of DOI:10.1021/jm00170a018

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