Synthesis, 470-MHz 1H NMR Spectra, and Activity of Delactonized Derivatives of the Anticancer Drug Etoposide

DOI: 10.1021/jm00351a014

Source and publish data:

Journal of Medicinal Chemistry p. 1077 - 1081 (1982)

Update date:2022-07-29

Topics:

Authors:

Jardine, Ian

Strife, Robert J.

Kozlowski, John

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00351a014

The anticancer drug etoposide (VP 16-213, 1) contains a highly strained trans-fused γ-lactone.This functionality is readily metabolized to an inactive ring-opened hydroxy acid (2).To prevent this detoxification of the drug and to investigate whether the l

Full text of DOI:10.1021/jm00351a014

Products guided by the article

Product name:(2R,4aR,6R,7R,8R,8aS)-6-[(5S,6R,7R,8R)-8-(4-Hydroxy-3,5-dimethoxy-phenyl)-6,7-bis-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxol-5-yloxy]-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

Cas No:82410-02-4

R&D Labs maybe for 82410-02-4

Changzhou Ruiping Chemical Co., Ltd

website:http://www.wishchem.com

Contact:+86-519-82324280

Address:No.288-1 Huacheng Road, Jintan
Beijing Harmony Chemical Co., Ltd.

Contact:86-010-84956928

Address:Room 207, Jin feng he B building, No 8 Xin Jie Kou Wai Street, Xi Cheng District, Beijing,PRC. 10008
HANGZHOU YUNUO CHEMICAL CO.,LTD

website:http://www.yunuochem.com

Contact:0571-83715115

Address:hangzhou
Guarson Chemical Co., Ltd.

website:http://www.guarson.com

Contact:+86-523-88059600,+86-13805268803

Address:Room B1006,Yafang Building,Jiangyan Avenue,Jiangyan District, Taizhou City,Jiangsu,China
SINFACHEM LIMITED

Contact:86-25-84683399

Address:605, Phoenix Herui Plaza, No.389, South Taiping Road, Nanjing, China 210002

Relevant to this article

Oxidation of some derivatives of tetrahydropyrimidine-5-carboxylic acid with selenium dioxide

Doi:10.1007/BF00503565
(1982)
Chemical aspects of propranolol metabolism: 1,1-Diethoxy-3-(1-naphthoxy)-2-propanol and related ring-closure products cis- and trans-4-ethoxy-3-hydroxy-3,4-dihydro-2H-naphtho[1,2-b]pyran

Doi:10.1002/jps.2600720807
(1983)
C-C Activation by Retro-Aldol Reaction of Two β-Hydroxy Carbonyl Compounds: Synergy with Pd-Catalyzed Cross-Coupling to Access Mono-α-arylated Ketones and Esters

Doi:10.1021/acs.joc.5b02098
(2016)
A novel design for porphyrin based D-s-A systems as molecular rectifiers

Doi:10.1039/c5sc03590b
(2016)
Hydration index-a better parameter for explaining small molecule hydration in inhibition of ice recrystallization

Doi:10.1021/ja806284x
(2008)
Total synthesis of (+)-discodermolide: An improved endgame exploiting a Still-Gennari-type olefination with a C1-C8 β-ketophosphonate fragment

Doi:10.1021/ol0478842
(2004)

Article Doi