Synthesis, 470-MHz 1H NMR Spectra, and Activity of Delactonized Derivatives of the Anticancer Drug Etoposide

DOI: 10.1021/jm00351a014

Source and publish data:

Journal of Medicinal Chemistry p. 1077 - 1081 (1982)

Update date:2022-07-29

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Authors:

Jardine, Ian

Strife, Robert J.

Kozlowski, John

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Article abstract of DOI:10.1021/jm00351a014

The anticancer drug etoposide (VP 16-213, 1) contains a highly strained trans-fused γ-lactone.This functionality is readily metabolized to an inactive ring-opened hydroxy acid (2).To prevent this detoxification of the drug and to investigate whether the l

Full text of DOI:10.1021/jm00351a014

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