Tetrahedron Letters p. 4915 - 4918 (1996)
Update date:2022-08-04
Topics:
Gayo, Leah M.
Suto, Mark J.
As part of our efforts in the area of combinatorial chemistry, we have been exploring new methods for the construction of combinatorial libraries in a bidirectional fashion. Herein, we describe a new one-pot procedure for the simultaneous protection/activation of amino and thiol carboxylic acids using pentafluorophenyl trifluoroacetate (TFAPfp) and related pentafluorophenyl reagents (FmocPfp and AcPfp).
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