OSMIUM-CATALYZED OXIDATION OF β-LACTAMS WITH PEROXIDES

DOI: 10.1016/S0040-4039(00)71260-3

Source and publish data:

Tetrahedron Letters p. 2145 - 2148 (1991)

Update date:2022-08-05

Topics:

Authors:

Murahashi, Shun-Ichi

Saito, Takao

Naota, Takeshi

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Article abstract of DOI:10.1016/S0040-4039(00)71260-3

Osmium-catalyzed oxidation of β-lactams with peroxides in acetic acid gives the corresponding 4-acetoxy β-lactams, which are versatile synthetic intermediate of carbapenem antibiotics, in good to excellent yields.

Full text of DOI:10.1016/S0040-4039(00)71260-3

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