Synthesis, cytotoxic effect and antiviral activity of 1-(β-D- arabinofuranosyl)-5-bromo-N4-substituted cytosine and 1-(β-D- arabinofuranosyl)-5-bromo-4-methoxypyrimidin-2(1H)-one derivatives

Article abstract of DOI:10.1080/07328319908044622

A convenient and mild synthesis of 5-bromo-N⁴-substituted-1-(β-D- arabinofuranosyl)cytosine and 5-bromo-O⁴-methyl-1-(β-D- arabinofuranosyl)pyrimidin-2(1H)-one derivatives by selective oxyfunctionalization of the corresponding 4-thionucleosides with 3,3- dimethyldioxirane is reported. The cytotoxicity and the antiviral activity against parainfluenza 1 (Sendai virus) of all new synthesized products are also reported.

Full text of DOI:10.1080/07328319908044622

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Nucleosides and Nucleotides
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Synthesis, Cytotoxic Effect and Antiviral
Activity of 1-(β-D-Arabinofuranosyl)-5-
Bromo-N4-Substitutedcytosine and 1-
(β-D-Arabinofuranosyl)-5-Bromo-4-
Methoxypyrimidin-2(1h)-One Derivatives
Raffaele Saladino a , Maurizio Mezzetti a , Enrico Mincione a , Anna
Teresa Palamara b , Patrizia Savini b & Stefano Marini b
a Dipartimento Agrochimico Agrobiologico , Università della Tuscia ,
Via S. Camilla de Lellis snc, 01100, Viterbo, Italy
b Dipartimento di Medicina Sperimentale e Scienze Biochimiche ,
Università “Tor Vergata” , Via di Tor Vergata 135, 00133, Roma, Italy
Published online: 04 Oct 2006.
To cite this article: Raffaele Saladino , Maurizio Mezzetti , Enrico Mincione , Anna Teresa Palamara ,
Patrizia Savini & Stefano Marini (1999) Synthesis, Cytotoxic Effect and Antiviral Activity of 1-(β-
D-Arabinofuranosyl)-5-Bromo-N4-Substitutedcytosine and 1-(β-D-Arabinofuranosyl)-5-Bromo-4-
Methoxypyrimidin-2(1h)-One Derivatives, Nucleosides and Nucleotides, 18:11-12, 2499-2510, DOI:
10.1080/07328319908044622
To link to this article: http://dx.doi.org/10.1080/07328319908044622
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