Journal of Medicinal Chemistry p. 1775 - 1777 (1983)
Update date:2022-08-03
Topics:
Archer
Seyed-Mozaffari
Osei Gyimah
Bidlack
Abood
14β-(2-Bromoacetamido)morphine (6) and 14β-(2-bromoacetamido)morphinone (9) were prepared preferably from the adduct of thebaine and 1-chloro-1-nitrosocyclohexane, which on reduction in methanol solution gave 14-aminocodeinone (2) and the corresponding ketal (3). When tested in a receptor-binding assay, the IC50 values of 6 and 9 were 15 and 10 nM, respectively. If the incubation time during the assay was increased from 15 to 30 min, irreversible binding of both ligands was observed.
View MoreShandong Xiangde Biotechnology Co., Ltd
Contact:+86 -15066639877
Address:Sanba street
Shanghai better-in Medical Technology Co.,LTD.
Contact:+86-21-38921049
Address:Lane 720 zhangjianggaoke cailun road, Pudong, Shanghai, room 513
Shanghai Mio Chemical Co., Ltd
Contact:0086 21- 64401188-622
Address:16 Floor NO.2 Jiefang Building, No. 4855 Dushi Road, 201100 Shanghai, P.R.China
Xi'an Kaixiang Photoelectric Technology Co., Ltd
website:http://www.kxmaterials.com/
Contact:86-29-15991651477
Address:Building 6, Biopharmaceutical Industry R&D Cluster Base, No. 16, Caotang 4th Road, Caotang Science and Technology Industrial Base, High-tech Zone, Xi'an City, Shaanxi Province, China
Taizhou volsen chemical Co., Ltd
website:http://www.volsenchem.com
Contact:+86-576-88869393
Address:Jiaojiang District, Taizhou, Zhejiang, China.
Doi:10.1021/jm060572f
(2006)Doi:10.1021/ja01528a034
(1959)Doi:10.1007/s10593-007-0064-3
(2007)Doi:10.1016/S0040-4039(00)88432-4
(1982)Doi:10.1021/jo00149a022
(1983)Doi:10.1002/ejoc.201402903
(2014)
