SYNTHESIS OF (+/-)-DESEPOXY-4,5-DIDEHYDROMETHYLENOMYCIN A

DOI: 10.1246/cl.1982.815

Source and publish data:

Chemistry Letters p. 815 - 816 (1982)

Update date:2022-08-02

Topics:

Authors:

Takahashi, Yasuhiro

Kosugi, Hiroshi

Uda, Hisashi

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Article abstract of DOI:10.1246/cl.1982.815

The reaction of methyl (E)-3-lithio-2-methyl-3-phenylthioprop-2-enoate (4) with methyl (E)-4-(t-butyldimethylsilyloxy)but-2-enoate (5) provides the functionalized cyclopentenone (6) in one step, which is transformed into both Koreeda's and Smith's intermediates (2) and (3) for synthesis of (+/-)-desepoxy-4,5-didehydromethylenomycin A (1).

Full text of DOI:10.1246/cl.1982.815

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