Synthesis and Pharmacological Characterization in Vitro of Cyclic Enkephalin Analogues: Effect of Conformational Constraints on Opiate Receptor Selectivity

Article abstract of DOI:10.1021/jm00354a008

Using a combination of solid-phase and solution methods, we synthesized a series of cyclic 5> enkephalin analogues by substitution of D-α,ω-diamino acids in position 2 of the enkephalin sequence and cyclization of the ω-amino group to the C