Synthesis and antihypertensive activity of stereoisomers of 4-piperidyl-1,3-dihydro-2-oxo-2H-benzimidazoles. Enhanced potencies of (+) isomers

DOI: 10.1021/jm00356a016

Source and publish data:

Journal of Medicinal Chemistry p. 208 - 213 (1983)

Update date:2022-07-30

Topics:

Authors:

Kasuya Kasuya

Shigenobu

Hashikami

Karashima

Obase Obase

Takai Takai

Teranishi

Karasawa

Kubo Kubo

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Article abstract of DOI:10.1021/jm00356a016

To elucidate the relationship between the pharmacological activity and stereochemical structure, we resolved 1-[2-(3,4,5-trimethoxyphenyl)-2-hydroxy-1-methylethyl]-4-(1,3-dihydro-2-ox o-2H-benzimidazol-1-yl)piperidine (1 and 2) and 1-[2-(3,4-dimethoxyphen

Full text of DOI:10.1021/jm00356a016

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