Synthesis and antihypertensive activity of stereoisomers of 4-piperidyl-1,3-dihydro-2-oxo-2H-benzimidazoles. Enhanced potencies of (+) isomers

DOI: 10.1021/jm00356a016

Source and publish data:

Journal of Medicinal Chemistry p. 208 - 213 (1983)

Update date:2022-07-30

Topics:

Authors:

Kasuya Kasuya

Shigenobu

Hashikami

Karashima

Obase Obase

Takai Takai

Teranishi

Karasawa

Kubo Kubo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00356a016

To elucidate the relationship between the pharmacological activity and stereochemical structure, we resolved 1-[2-(3,4,5-trimethoxyphenyl)-2-hydroxy-1-methylethyl]-4-(1,3-dihydro-2-ox o-2H-benzimidazol-1-yl)piperidine (1 and 2) and 1-[2-(3,4-dimethoxyphen

Full text of DOI:10.1021/jm00356a016

Products guided by the article

Product name:erythro-1-<2-(3,4,5-trimethoxyphenyl)-2-hydroxy-1-methylethyl>-4-(3-acetyl-2-oxo-1,3-dihydro-2H-benzimidazol-1-yl)piperidine

Cas No:83665-45-6

R&D Labs maybe for 83665-45-6

Yancheng Smiling Imp & Exp Co., Ltd.

Contact:+86-515-83173586

Address:Rm1207, BLD#03, Phoenix Plaza, Juheng Road, Yancheng, Jiangsu, P.R. China
Xi'an Tizan Tech & Industry Co., Ltd.

Contact:86-18629066522

Address:C3009 TANG FENG INTERNATIONAL PLAZA, NO.18 FENGHUI NAN ROAD, XI'AN HIGH TECH ZONE, 710075 CHINA.
taizhou creating bio-pharm co.,ltd.

Contact:+86- 576- 88827176

Address:715 room ,unit A.junyue Building,Jiaojiang,Taizhou,Zhejiang,China
Weifang Adde Economic And Trade Co.,LTD.

Contact:86-536-8885548

Address:Room 1402,Wanda Plaza B Block,No.958,Yuanfei Road,Kuiwen District
Anhui Redstar Pharmaceutical Corp., Ltd

Contact:+86-563-5120837

Address:Jingxian Industrial Development Zone, Anhui , China

Relevant to this article

The cocondensation reaction of lithium atoms and anisole: An experimental and theoretical study of the reaction pathway

Doi:10.1016/j.jorganchem.2004.12.016
(2005)
Practical Asymmetric Syntheses if 11-Deoxydaunomycine and Related Compounds

Doi:10.1021/ja00389a103
(1982)
Propagation rate of the cationic polymerization of 2,4,6-trimethylstyrene: A linear free energy approach

Doi:10.1021/ma048389o
(2005)
Sulfenic acids from L-cysteine involved in the synthesis of alliin analogues

Doi:10.1080/10426500590910792
(2005)
REACTIONS OF METHYLQUINOXALINE DI-N-OXIDES WITH ALDEHYDES OF THE BENZENE AND FURAN SERIES

Doi:10.1007/BF00772174
(1982)
Syntheses of 4-alkoxy-3-methoxy-5H-benzocycloheptenes and 2-alkoxy-3-methoxy-5H-benzocycloheptenes from isovanillin via Claisen rearrangement and ring-closing metathesis

Doi:10.1002/jccs.200400122
(2004)

Article Doi