Synthesis and antihypertensive activity of stereoisomers of 4-piperidyl-1,3-dihydro-2-oxo-2H-benzimidazoles. Enhanced potencies of (+) isomers

DOI: 10.1021/jm00356a016

Source and publish data:

Journal of Medicinal Chemistry p. 208 - 213 (1983)

Update date:2022-07-30

Topics:

Authors:

Kasuya Kasuya

Shigenobu

Hashikami

Karashima

Obase Obase

Takai Takai

Teranishi

Karasawa

Kubo Kubo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00356a016

To elucidate the relationship between the pharmacological activity and stereochemical structure, we resolved 1-[2-(3,4,5-trimethoxyphenyl)-2-hydroxy-1-methylethyl]-4-(1,3-dihydro-2-ox o-2H-benzimidazol-1-yl)piperidine (1 and 2) and 1-[2-(3,4-dimethoxyphen

Full text of DOI:10.1021/jm00356a016

Products guided by the article

Product name:erythro-1-<2-(3,4,5-trimethoxyphenyl)-2-hydroxy-1-methylethyl>-4-(3-acetyl-2-oxo-1,3-dihydro-2H-benzimidazol-1-yl)piperidine

Cas No:83665-45-6

R&D Labs maybe for 83665-45-6

AURORA CHEMICAL CO., LTD

Contact:86-532-68629711 13780605697

Address:NO 220 YANAN 3 ROAD,(POST ADMINISTRATION BUILDING),QINGDAO,CHINA
Shijiazhuang Sdyano Fine Chemical Co., Ltd

Contact:+86-311-89830448

Address:NO.48 Ta Nan Road,Yuhua District,Shijiazhuang,Hebei,China
Chengdu Baishixing Science and Technology Industry Co., Ltd.

website:http://www.cd-bsx.com

Contact:+86-28-88531548

Address:#217,North of Industry Road,Heshan Town,Pujiang County,Chengdu,Sichuan,China.
GIHI CHEMICALS CO.,LIMITED

Contact:+86-571-86217390

Address:No.567 Dengcai Street,Sandun,Westlake District,Hangzhou310030,Zhejiang,China.
CHINA MEHECO CORPORATION

Contact:+86-10-67147360/67107388

Address:No.18 Guangming Zhongjie, Chongwen District, Beijing, 100061, China

Relevant to this article

The cocondensation reaction of lithium atoms and anisole: An experimental and theoretical study of the reaction pathway

Doi:10.1016/j.jorganchem.2004.12.016
(2005)
Practical Asymmetric Syntheses if 11-Deoxydaunomycine and Related Compounds

Doi:10.1021/ja00389a103
(1982)
Propagation rate of the cationic polymerization of 2,4,6-trimethylstyrene: A linear free energy approach

Doi:10.1021/ma048389o
(2005)
Sulfenic acids from L-cysteine involved in the synthesis of alliin analogues

Doi:10.1080/10426500590910792
(2005)
REACTIONS OF METHYLQUINOXALINE DI-N-OXIDES WITH ALDEHYDES OF THE BENZENE AND FURAN SERIES

Doi:10.1007/BF00772174
(1982)
Syntheses of 4-alkoxy-3-methoxy-5H-benzocycloheptenes and 2-alkoxy-3-methoxy-5H-benzocycloheptenes from isovanillin via Claisen rearrangement and ring-closing metathesis

Doi:10.1002/jccs.200400122
(2004)

Article Doi