2,4-Diamino-6,7-dimethoxyquinazolines. 3. 2-(4-Heterocyclylpiperazin-1-yl) Derivatives as α1-Adrenoceptor Antagonists and Antihypertensive Agents

Article abstract of DOI:10.1021/jm00393a019

A series of 4-amino-6,7-dimethoxy-2-(4-heterocyclylpiperazin-1-yl)quinazolines (3) was prepared and screened for α-adrenoceptor affinity and antihypertensive activity.These quinazoline derivatives showed high binding affinity (ca. 10^-10 M) and