2,4-Diamino-6,7-dimethoxyquinazolines. 3. 2-(4-Heterocyclylpiperazin-1-yl) Derivatives as α1-Adrenoceptor Antagonists and Antihypertensive Agents

DOI: 10.1021/jm00393a019

Source and publish data:

Journal of Medicinal Chemistry p. 1794 - 1798 (1987)

Update date:2022-09-26

Topics:

Authors:

Campbell, Simon F.

Plews, Rhona M.

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Article abstract of DOI:10.1021/jm00393a019

A series of 4-amino-6,7-dimethoxy-2-(4-heterocyclylpiperazin-1-yl)quinazolines (3) was prepared and screened for α-adrenoceptor affinity and antihypertensive activity.These quinazoline derivatives showed high binding affinity (ca. 10^-10 M) and

Full text of DOI:10.1021/jm00393a019

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