Journal of Medicinal Chemistry p. 451 - 455 (1983)
Update date:2022-08-05
Topics:
Bernhart
Condamine
Demarne
Roncucci
Gagnol
Gautier
Serre
The synthesis of new [(dialkylamino)alkyl]pyridylacetamides is reported. These compounds displayed a potent antiarrhythmic activity, as demonstrated on a model of myocardial infarction in the conscious dog. Structure-activity relationships are discussed within a series of 22 homologues, comparing relative antiarrhythmic properties and cardiac side effects. One of these compounds, 15, has been selected as a candidate for clinical evaluation in man.
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