AN APPROACH TO VINDOLINE SKELETON UTILIZING SUBSTITUTED METHYLENETETRAHYDROFOLATE (5,10-CHR-THF) MODELS

DOI: 10.1016/S0040-4039(01)80200-8

Source and publish data:

Tetrahedron Letters p. 1513 - 1516 (1984)

Update date:2022-08-03

Topics:

Authors:

Pandit, U.K.

Bieraeugel, H.

Stoit, A.R.

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Article abstract of DOI:10.1016/S0040-4039(01)80200-8

Starting from substitued methylenetetrahydrofolate model (4-(2-N(1)-tosyl-N(3)-methyl-4,4-dimethylimidazolidyl)-3-ketobutanoate), an efficient synthesis of the pentacyclic system corresponding to vindoline is described.

Full text of DOI:10.1016/S0040-4039(01)80200-8

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