Concise synthetic strategy toward cyclic α,α-disubstituted α-amino acids bearing a δ-nitrogen atom: Chiral 1-substituted 4-aminopiperidine-4-carboxylic acids

Article abstract of DOI:10.1016/j.tet.2004.11.004

A concise synthetic strategy toward cyclic α,α-disubstituted α-amino acids, 1-substituted 4-aminopiperidine-4-carboxylic acids have been developed. The synthetic route is a reductive amination of dimethyl bis(dioxolanemethyl)malonate with various amines,