PALLADIUM(II)-CATALYZED DOUBLE CARBONYLATION OF ORGANIC HALIDES IN THE PRESENCE OF AMINES: α-KETOAMIDE SYNTHESIS

Article abstract of DOI:10.1016/S0022-328X(00)85589-8

Aryl, hetero-aryl, and vinylic halides react with carbon monoxide (40 atm pressure or less) and a secondary amine at 60-100 deg C in the presence of a catalytic amount of palladium compound to form α-ketoamides, in addition to simple amides as by-products.When a primary amine was used in place of a secondary one, an imine of the α-ketoamide was readily obtained.