Design, synthesis, and biological evaluation of alcyopterosin a and illudalane derivatives as anticancer agents

DOI: 10.1016/j.bmc.2005.10.033

Source and publish data:

Bioorganic and Medicinal Chemistry p. 1863 - 1870 (2006)

Update date:2022-08-04

Topics: Synthesis Structure-Activity Relationship (SAR) Analysis Animal Studies Literature Review Biological Evaluation Toxicity Assessment Formulation Development Data Analysis and Reporting Target Identification Publication and Peer Review Mechanism of Action Studies Regulatory Compliance Design and Molecular Modeling

Authors:

Finkielsztein, Liliana M.

Bruno, Ana M.

Renou, Sergio G.

Moltrasio Iglesias, Graciela Y.

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Article abstract of DOI:10.1016/j.bmc.2005.10.033

The synthesis of alcyopterosin A and a series of new derivatives possessing an illudalane skeleton is described. The DNA binding properties of these compounds have been examined and compared to those of reference drugs using a UV spectroscopy technique. T

Full text of DOI:10.1016/j.bmc.2005.10.033

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