A NEW SYNTHETIC METHOD OF α,Β-UNSATURATED KETONES VIA REGIOSELECTIVE REACTION OF ALLYL ANION FORMED FROM 2-MORPHOLINO-3-BUTENENITRILES (MASKED ACYL ANION EQUIVALENTS) WITH ALKYL HALIDES FOLLOWED BY HYDROLYSIS

Article abstract of DOI:10.1246/cl.1982.1263

Treatment of 2-morpholino-3-butenenitriles and alkyl halides regioselectively afforded products alkylated on α-position to the nitrile group.The hydrolysis of the α-alkylation products gave the α,β-unsaturated ketones in good yields.