Potential antipsychotic agents. 9. Synthesis and stereoselective dopamine D-2 receptor blockade of a potent class of substituted (R)-N-[(1-benzyl-2-pyrrolidinyl)methyl]benzamides. Relations to other side chain congeners

DOI: 10.1021/jm00107a012

Source and publish data:

Journal of Medicinal Chemistry p. 948 - 955 (1991)

Update date:2022-08-04

Topics:

Authors:

Hogberg Hogberg

Strom Strom

De Paulis

Stensland

Csoregh Csoregh

Lundin Lundin

Hall Hall

Ogren Ogren

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Article abstract of DOI:10.1021/jm00107a012

A number of substituted N-[(1-benzyl-2-pyrrolidinyl)methyl]benzamides and -salicylamides have been prepared and investigated as dopamine D-2 receptor antagonists in vitro and in vivo. The affinity was found to be confined to the R enantiomer, in contrast

Full text of DOI:10.1021/jm00107a012

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